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Series GSE57714 Query DataSets for GSE57714
Status Public on Jan 30, 2015
Title Gene expression profiling in the endometrium of pregnant mammals
Organisms Ornithorhynchus anatinus; Dasypus novemcinctus; Canis lupus familiaris
Experiment type Expression profiling by high throughput sequencing
Summary A major challenge in biology is to determine how evolutionarily novel characters originate, however, mechanistic explanations for the origin of novelties are almost completely unknown. The evolution of mammalian pregnancy is an excellent system in which to study the origin of novelties because extant mammals preserve major stages in the transition from egg-laying to live-birth. To determine the molecular bases of this transition, we characterized the pregnant/gravid uterine transcriptome from tetrapods, including species in the three major mammalian lineages, and used ancestral transcriptome reconstruction to trace the evolutionary history of uterine gene expression. We show that thousands of genes evolved or lost uterine expression during the origins of mammalian pregnancy, including the loss of genes responsible for the mineralization of the eggshell in the Mammalian and Therian stem-lineages, and the recruitment of genes into uterine expression that mediate maternal-fetal communication and maternal immunotolerance of the fetal allograft in the Therian and Eutherian stem-lineages. Our results indicate that one of the defining mammalian novelties evolved through a step-wise process that dramatically changed uterine gene expression, generating a suite of evolutionary innovations that support prolonged gestations.
Overall design We report genome-wide gene expression generated by mRNA-Seq from the pregnant endometrium of dog, armadillo, and the platypus.
Contributor(s) Lynch VJ, Emera D
Citation(s) 25640180
Submission date May 15, 2014
Last update date May 15, 2019
Contact name Vincent J. Lynch
Organization name The University of Chicago
Department Human Genetics
Street address 920 E. 58th Street
City Chicago
ZIP/Postal code 60637
Country USA
Platforms (3)
GPL13923 Illumina Genome Analyzer II (Dasypus novemcinctus)
GPL18701 Illumina Genome Analyzer II (Canis lupus familiaris)
GPL18702 Illumina Genome Analyzer II (Ornithorhynchus anatinus)
Samples (3)
GSM1387172 mRNA-Seq data from pregnant dog endometrium
GSM1387173 mRNA-Seq data from pregnant armadillo endometrium
GSM1387174 mRNA-Seq data from pregnant platypus endometrium
BioProject PRJNA247824
SRA SRP042024

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE57714_RAW.tar 500.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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